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In human HT-1080 fibrosarcoma cells, treatment of erastin (Era) restricts the production of glutathione ( Supplementary Figure S13 ), and therefore inactivates GPX4 and triggers ferroptosis ( 102 prevented erastin-induced ferroptosis evidently in a dose-dependent manner ( Figure 8A ), even when the concentration of erastin reached to 100 M ( Figure 8B )

Because there are so few human studies, we do not have a clear picture of long-term safety

BNIP3L was initially reported to be involved in mitochondrial clearance during erythrocyte maturation, but subsequent studies have revealed its role in various cell types [138]

7 NADP(H) is predominantly bound to intracellular proteins with different affinities

To assess the combined effect of both stimuli, an additional experiment was conducted using a mixed solution of glutathione (8.0 mM) and amidase (100 U/L)