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A key regulator of NRF2 activity is kelch-like ECH-associated protein 1 (KEAP1), which acts as a ROS sensor and principal suppressor of NRF2

Collectively, our findings provide new experimental and statistical support for a novel mechanistic framework in which LC ameliorates energy metabolism remodeling by suppressing PI3K/Akt signaling to upregulate PGC-1

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However, hypoxic conditions and high concentrations of reduced GSH in the TME conspicuously compromise the antitumor effect of PDT

Of equal concern is the fact that unregulated peptides may be contaminated with impurities, according to the FDA