The Dual PI3 kinase/mTOR inhibitor PI-103 prevents p53 induction by Mdm2 inhibition but enhances p53-mediated mitochondrial apoptosis in p53 wild-type AML
The tradeoff is that it's less researched than L-Ascorbic Acid, but the stability and tolerability advantages make it a smart choice for anyone who has struggled with traditional Vitamin C formulas
Barone, R., Simpore, J., Malaguarnera, L., Pignatelli, S
And while human anecdotal and case reports are abundant, human clinical research remains limited, and we would ultimately like to see more well-designed human studies in the near future
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