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In cases where metformin is not suitable or not sufficient to achieve target blood glucose levels, healthcare providers may consider adding or switching to other medications, such as GLP-1s, DPP-4 inhibitors, SGLT-2 inhibitors, or insulin

A lack of electrolytes, such as sodium and potassium, can also interfere with your hearts rhythm and your nervous systems ability to maintain steady blood pressure

Current Access Landscape Neither Mazdutide nor Retatrutide has received Health Canada approval as of late 2025

They support different but complementary functions in the body, especially when it comes to long-term skin health

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