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Subjective improvement in pain, function, and activity tolerance provides the primary effectiveness signal

[3] B12 is the most chemically complex of all the vitamins

That is not a risk worth taking

Although there is currently no evidence to suggest any adverse side effects from excess vitamin B12 supplementation, there is no need to take excessively high amounts of the vitamin, as the body can only absorb so much anyway

- High-dose oral B12 treatment Instead of taking the injection route, a provider may prescribe a high-dose B12 oral treatmenta pill, capsule, or lozenge containing a higher concentration of B12 than your average over-the-counter (OTC) supplement