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After a meaningful gap of several weeks or more, the tolerance your body built up during the original slow titration fades, so a clinician typically has you restart at a lower dose and titrate back up

16 This shifts the narrative from fearing an inevitable side effect to embracing a manageable challenge

The upregulation of the tumour suppressor gene P53 leads to the accumulation of lipid hydroperoxides by inhibiting the expression of SLC7A11 and reducing the level of GSH, eventually triggering ferroptosis [81]

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Injection Site Reactions: For injectable GLP-1 agonists, local reactions such as redness, swelling, or itching at the injection site may occur