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FDA previously identified concerns including limited human safety information, possible immunogenicity, reproductive findings in nonclinical research, and the possibility of tumor-promoting activity in certain tissues

In some countries, tesofensine might be available through specific compassionate use programs or special access schemes for medications still under investigation

Although each of these systems had merit, the use of retrovirus pseudoparticles (HCVpp) has provided the most insight into HCV entry

Journal of the American Heart Association, 13 (11), Article e034991

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