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Animal studies demonstrated dose-dependent and treatment-duration-dependent increases in thyroid C-cell tumours in rodents treated with GLP-1 receptor agonists
The physical changes at this point are subtle
HIF-1 is activated due to blockade of its degradation pathway mediated by low oxygen levels, thereby increasing the expression of target genes, including those encoding glycolytic enzymes and glucose transporters, and increasing lactate secretion 67
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