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This distinction is important because while blocking COX-2 provides the anti-inflammatory benefits, blocking COX-1 can lead to side effects like stomach problems (Daniels et al., 2016
As mentioned above, the link between TNF- and ROS adds another dimension of complexity to the TNF signaling network, as ROS act on numerous proteins required for the regulation of cellular homeostasis, including proteins that mediate cell proliferation, survival, death, differentiation, DNA repair and metabolism 30
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