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The safety and efficacy of once daily lnsulin glargine administered pre-breakfast or at bedtime were also evaluated in a randomized, active-controlled clinical study (Study I, n = 697) in patients with type 2 diabetes not adequately controlled on oral anti-diabetic therapy

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Chromatographic Separation: A reverse-phase C18 column with a gradient elution profile was used to separate GSH and GSSG from other metabolites

Patients in trials reported less breathlessness, better ability to walk or exercise, improved quality of life scores, weight loss, and better functional capacity

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