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They conclude: Given the severe societal, familial, and economic burden of diabetes-related dementia, these findings raise important considerations about the role of GLP-1 [receptor agonists] as first-line therapies in [type 2 diabetes] management
"The novel GIP, GLP-1 and glucagon receptor agonist retatrutide delays gastric emptying." Diabetes, Obesity and Metabolism
Interleukin inhibitors : Ustekinumab (Stelara) targets IL-12 and IL-23 pathways, while risankizumab (Skyrizi) specifically inhibits IL-23
Preclinical studies have also revealed that dual agonists of GLP-1R and glucose-dependent insulinotropic polypeptide receptor (GIPR) have synergistic anti-inflammatory and neuroprotective effects, suggesting the potential advantages of multitargeting strategies (Yuan et al., 2024)