6 mg of tirzepatide – 60 Vial Confused why 16.6mg : r/tirzepatidecompound

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The GLP-1 released into the body after eating is mostly stored in L cells, or intestinal endocrine cells

Incretins are hormones released from the gastrointestinal tract into systemic circulation and are involved in glycemic regulation

Some clinical observations suggest that while the dual action can lead to more significant weight loss, it may also lead to a more pronounced feeling of tiredness in the initial stages compared to GLP-1 alone

466 One study proposed a novel mechanism wherein postprandial GLP-1 release, under normal physiological conditions, inhibits the activity of chemosensory cells in the carotid body, thereby counteracting sympathetic excitability mediated by elevated blood glucose or insulin levels