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This occurs because the medications effects on appetite suppression and metabolic control diminish once treatment is discontinued

The maximum dosage of Ozempic is 2 mg weekly and the maximum dosage of Wegovy is 2.4 mg weekly

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Specific expression of the GLP-1R in beta-cells also leads to a high expression in insulinomas (91), indeed, labeled GLP-1R ligands have been suggested as an imaging tool for detection of such tumors (92)