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This can lead to drug or metabolite accumulation due to reduced hepatic function, altered enzyme activity, and impaired bile flow, thereby increasing the risk of DILI [85]

This ceiling effect is important

Anti-inflammatory signalling (preclinical): KPV has shown anti-inflammatory activity via NF-B in cell studies [11]

The strategy was designed to exploit methodological complementarity and reduce model-specific bias through consensus-driven prioritization across multiple screening routes