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Variants in GIPR (the GIP receptor that tirzepatide also activates), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide
While the medication has demonstrated significant efficacy in glycaemic control, it can produce various side effects as the body adjusts
Splitting a single weekly dose across two separate injections on consecutive days is not recommended and fundamentally changes the pharmacokinetic profile of the medication
But studies now show that it can also help people lose weight
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