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In vitro, OGD-induced ferroptosis was ameliorated by GSH, which restored cell proliferation, reduced oxidative stress, and upregulated ferroptosis defense factors

doi: 10.1177/1091581810385957

755 Mechanistically, SSAT1 overexpression increases ALOX15 expression and decreases the expression levels of GPX4 and SLC7A11 in primary cortical neurons, suggesting that SSAT1/ALOX15 axis activation may aggravate brain I/R injury by triggering ferroptosis in neurons

The NICE guidelines on obesity management do not include B12 supplementation as a therapeutic option for weight reduction in the absence of documented deficiency

For some, it rebounds beyond pre-treatment levels temporarily before normalizing