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Energy tends to respond first, mood and focus follow within a week or so, and the longer-term, structural benefits build quietly over months

This makes it less likely to cause systemic side effects like water retention, insulin resistance, or abnormal growth of tissues

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This is probably explained by the fact that S-adenosylmethionine (SAM), which is important for many epigenetic processes, is regenerated by methylcobalamin, whereas cyanocobalamin reduces it (as we explored above)

Metagenomic biomarker discovery and explanation (in Eng)