The interaction mechanism involves altered absorption pathways and changes in redox balance
Magnesium is a macromineral required for hundreds of the body's biochemical reactions including protein synthesis, muscle and nerve function, blood glucose control, bone development, DNA synthesis, and glutathione synthesis
It protects cells, detoxifies the liver, and supports the immune system
A meta-analysis of Harmony Outcomes and AMPLITUDE-O included 13,538 patients, of whom 1,193 (8.8%) used SGLT2 inhibitors
Less commonly, patients have reported pancreatitis and gallstones due to sluggish flow of intestinal fluids as well as bowel obstruction due to slowed intestinal motility