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2022 AHA/ACC/HFSA guideline for the management of heart failure: Executive summary: A report of the American college of cardiology/American heart association joint committee on clinical practice guidelines

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Studies indicate dual (OR = 3.258) or triple (OR = 8.226) anti-obesity therapy substantially elevates risk potential compared to monotherapy

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Patients with sustained lifestyle improvements regain less weight than those who relied only on medication