semaglutide patent novo nordisk to lose blockbuster drug over small fee Novo Nordisk opens new front

Clinically significant hypoglycemia occurred in 20 adults receiving orforglipron, and severe hypoglycemia occurred in one participant

[24] Hypertrophy of the extraocular muscles, adipogenesis, and deposition of nonsulfated glycosaminoglycans and hyaluronate, causes expansion of the orbital fat and muscle compartments, which within the confines of the bony orbit may lead to dysthyroid optic neuropathy, increased intraocular pressures, proptosis, venous congestion leading to chemosis and periorbital edema, and progressive remodeling of the orbital walls

Jo WK, Drosten C, Drexler JF

Clin Nutr (2021) 40:33327

One option is a TRT program, which is built around ongoing monitoring