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By slowing the rate at which the stomach empties its contents into the duodenum, GLP-1 agonists prolong the sensation of fullness, contribute to reduced caloric intake, and moderate postprandial glucose excursions

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Drugs that require rapid absorption or have narrow therapeutic windows may need timing adjustments

Contraindicaciones Absolutas Los agonistas GLP-1 estn contraindicados en: antecedente personal o familiar de carcinoma medular de tiroides (CMT), sndrome de neoplasia endocrina mltiple tipo 2 (MEN 2), pancreatitis crnica severa, embarazo y lactancia

It was first characterized by Raun et al