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Unfortunately, this trial did not phenotype patients as T2 high or low, which might limit some of their conclusions for the future utility based on the correct patient population [96]

Specifically, we defined a percentage BMI change phenotype as: where BMI 1 and BMI 2 represent pre-treatment and post-treatment BMI, respectively, measured in weight in kilograms per height in metres squared

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T2D-associated risk alleles (e.g., KCNJ11, SLC30A8, HNF1A) are enriched in regulatory regions of less functional cells -cells