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Later work examined NNMT inhibition combined with dietary changes in obese mice, reporting reductions in body weight, fat mass, and hepatic fat, alongside shifts in gut bacterial populations
Moreover, it has been recently proven that IGF-1 central administration also induced improvement in insulin sensitivity [291], meaning that this sudden rise after exercise or treatment could be of benefit not only in the periphery, but acting centrally
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[12] Animal reproduction studies have not demonstrated teratogenicity, and historical clinical use suggests low embryotoxic risk when lidocaine is administered at recommended dosages
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