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Supporting this hypothesis, we demonstrate that GLP-1 receptor-mediated targeting of MK-801 effectively avoids other adverse effects associated with MK-801 monotherapy, including hyperthermia and hyperlocomotion

Med 11 , e382 (2021)

Following MCAo surgery, post-operative care was done by saline infusion, body temperature maintenance, analgesia, liquid diet supply, and closed monitoring of the animals placed in individual ventilated cages

Injectable L-carnitine (IM, 500mg-1g) bypasses both the oral bioavailability problem and the GI issues GLP-1 users already experience oral L-carnitine has only ~14% absorption, and gut bacteria convert the unabsorbed remainder to TMAO (trimethylamine N-oxide), a cardiovascular risk biomarker

It's a powerful medication, but tirzepatide's dual GIP and GLP-1 receptor action often gives it a statistical edge