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It is a common form of heart failure in patients with obesity, hypertension, and metabolic syndrome, and it has become a recognized clinical target for incretin-based therapy following the STEP-HFpEF trial (semaglutide in HFpEF with obesity) and the SUMMIT trial (tirzepatide in obesity-related HFpEF)
10.1093/nutrit/nuv111 40 MalobertiA.BossiI.TassistroE.ReboraP.RacioppiA.NavaS.et al (2021)
Acylated GLP-1RAs, like liraglutide and semaglutide, heve limited direct BBB penetration but still reach critical areas such as the arcuate nucleus (ARH) through indirect pathways [125]
Vitamin D deficiency is common and causes muscle pain and weakness
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