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While there is no direct drug-drug interaction between Wegovy and Wellbutrin, several safety considerations warrant attention when these medications are used together

Orthostatic considerations Orthostatic hypotension (a drop of 20 mmHg systolic or 10 mmHg diastolic on standing) can develop during early treatment for several reasons: Reduced fluid intake from nausea Reduced sodium intake from decreased eating Continued full-dose antihypertensive medications as BP drops Volume contraction from weight loss Patients should be counseled to rise slowly, maintain hydration, and contact their clinician if they experience dizziness on standing

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Most people find it best to take these supplements in the morning on an empty stomach, or about 20 minutes before a meal

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