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they occur over a period of several months

Fredericson says that although some professional athletes tout high starting doses of creatine supplements, be mindful that those larger 20 g loading doses can be excessive for the average person and can increase water retention

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In a large study in more than 5000 participants with type 2 diabetes, it was shown that poor glycaemic control was associated with anhedonia but not depression or anxiety [119], suggesting that anhedonia may be more important than general depression scores

For some people, weeks 3 and 4 bring a slight reduction in the appetite-suppressing effect compared to week 1