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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Mounjaro) and chronic weight management (Zepbound) in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, as an adjunct to diet and physical activity

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By modulating the structure and function of tumor blood vessels through normalization, disruption, or remodeling, NP-based strategies can substantially improve drug penetration, immune cell infiltration, and overall therapeutic outcomes