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Psychiatry 25 , 17871808 (2020)

& Sutovsky, P

During hypoxia, the metabolic flow of glucose changes to reduce acetyl-CoA and promote lactate production

Mutations in the lysyl hydroxylase 1 gene that result in enzyme deficiency and the clinical phenotype of EhlersDanlos syndrome type VI

61,62,63 CDO is highly regulated at the level of protein turnover, as oxidative degradation of cysteine by CDO is highly inducible, 64 and high cysteine levels inhibit CDO ubiquitinylation and reduce its proteasomal degradation