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In this case, the affinity would weaken if Glu was replaced with a lactam bridge because the charge would be dispersed

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"Gamma-glutamyltransferase and risk of cardiovascular mortality: A dose-response meta-analysis of prospective cohort studies." PLoS One

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Lab Invest

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Administering a single dose of acetyl-L-carnitine intravenously (by IV) seems to produce short-term improvements in blood flow in the brains of people who have poor blood circulation in the brain

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Food and Drug Administration for any human or veterinary indication

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