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Regardless, patients with TDP-43 mutations have TDP-43 pathology, and the mouse model that have A315T mutation has TDP-43 accumulations mostly in the nucleus, have extensive ubiquitinated protein accumulations in the cytoplasm, and based on the antibody used, pTDP-43 are also detected in the cytoplasm 19,46
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In a patient with an undiagnosed tumor, the same mechanism could potentially accelerate tumor growth and metastasis
Codes vary widely based on procedure complexity
The rates of adverse events in trials were similar to placebo groups
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