We can overcome the common difficulties encountered in cell-based expression system, such as misfolding, aggregation, inactivity, high endotoxin, poor stability and solubility, etc
This means attending NHS health checks when invited (available to those aged 40 to 74), discussing blood pressure, cholesterol, and blood glucose screening with a GP, being aware of bowel cancer screening (offered to those over 60 in the UK), having conversations about prostate health from the mid-forties onward for those with risk factors, and not dismissing symptoms or delaying seeking help when something feels wrong
Swapping in the triple agonist is the upgrade path, with the trade-off being that the specific pairing has not been formally trialed
BMJ Open Gastroenterology, 7 (1), e000368
We need a more sophisticated conversation about pharmaceutical value rather than killing the golden goose, especially given that we all want the benefits