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Although most patients experience grade 1-2 pneumonitis, it can rapidly escalate to a grade 3-4 irAE with a high mortality rate (50%-60%)
Hepatic and Metabolic Benefits A MAFLD/MASLD (metabolic dysfunction-associated steatotic liver disease) sub-study of the Phase 2 obesity trial reported that over 85% of participants on the highest retatrutide doses achieved more than 30% reduction in liver fat content measured by MRI, with many reaching complete resolution of steatosis
It has been extensively studied for its role in melanogenesis and various physiological processes
The widespread distribution of GLP-1 receptors means that activating them produces ripple effects across multiple organ systems, and each new study reveals additional potential applications
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