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In its hyphal state, Candida produces specialised invasins and proteinases including candidalysin, a peptide toxin that physically puncture intestinal epithelial cells, widen tight junctions between cells, and allow the yeast itself and its toxic metabolites to translocate into the bloodstream and lymphatic system

Previous studies in CNS point to inflammatory mediators as triggers of the dysfunctional autophagy-lysosomal pathway

In addition, with its origins in -MSH, KPV has demonstrated therapeutic value related to immune function, namely antimicrobial and wound-healing potential

Inorg Chem 59:35703578 Shano LB, Karthikeyan S, Kennedy LJ, Chinnathambi S, Pandian GN (2024) MOFs for next-generation cancer therapeutics through a biophysical approacha review

However, the larger ACT trial (n=2,308) did not confirm this benefit (ACT Investigators, Circulation, 2011) [68]