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Finally, a phase 2 study in subjects with metabolic dysfunction-associated steatohepatitis (MASH) and fibrosis at doses of 2.4 mg, 4.8 mg, and 6.0 mg, compared to placebo over 48 weeks, results in significant improvement of liver fat content and fibrosis, with mean weight reductions of 10%, 13%, 13%, and 0.7%, respectively (98)

Although improved insulin sensitivity was an outcome of this study, this cannot be generalized to a human population due to the use of mice, as well as the lack of whole-body insulin sensitivity measures

This is particularly important for individuals with additional risk factors such as renal impairment, elderly patients, those taking multiple glucose-lowering medications, or anyone with a history of gastrointestinal disorders or pancreatitis

Progression of retinopathy with glucagon-like peptide-1 receptor agonists with cardiovascular benefits in type 2 diabetes: a systematic review and meta-analysis

In rodents, stimulation of GLP-1 receptors in thyroid C cells promotes the secretion of calcitonin