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A compromised gut lining is linked to systemic inflammation, brain fog, fatigue, skin issues, and mood disturbances via the gut-brain axis

240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5

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Within group analyses of efficacy endpoints were assessed using the Students paired t -test or, in cases of intractable non-normality, the Wilcoxon Signed-Rank test

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