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Another patient may tolerate topiramate at a modest dose but require gradual increases in phentermine over several weeks
The article states plainly that no randomized controlled trials exist comparing dual therapy to either agent alone, and that no major clinical guideline currently recommends the combination as standard therapy
Lowering the dose for a few weeks or slowing the schedule can help minimize side effects, making the medicine easier to stick with
Ratliff J, Leite JO, de Ogburn R, Puglisi MJ, VanHeest J, Fernandez ML
The most significant changes were observed at the highest dosages of tirzepatide, i.e., 10 and 15 mg [89, 90]
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