Before booking, think about your goals, previous diets or medications, current prescriptions, sleep, stress, work schedule, eating patterns, and budget
Native amylin is notoriously difficult to work with because it aggregates to form amyloid fibrils (a property exploited by the pancreatic amyloid deposits seen in T2D progression)
Unfortunately, glucocorticoids have a number of undesirable side effects such as muscle wasting, fat gain, and deterioration of bone density
This is not surprising, considering that tirzepatide and semaglutide evoked more pronounced TBWL and also have glucose-lowering effects by slowing gastric emptying, stimulating insulin secretion and inhibiting glucagon secretion in a glucose-dependent manner, independent of their effects on body weight 50,51
Monitor liver enzymes (ALT, AST), metabolic parameters (HbA1c, lipids), and fibrosis scores (FIB-4) every 36 months