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The combination of all four pathways should theoretically produce earlier onset of appetite suppression, more sustained fullness between meals, increased resting energy expenditure from the glucagon component, and a reduced tendency toward the metabolic adaptation that commonly causes weight loss plateaus on single-agent therapy

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Mansoor, K., Bardees, R., Alkhawaja, B., Mallah, E., AbuQatouseh, L., Schmidt, M., & Matalka, K

The treatment arm achieved an 18 percent mean reduction in visceral adipose tissue versus a small increase in placebo, with statistically significant improvements in triglycerides (minus 50 mg/dL), total cholesterol, and patient-reported body image