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We hypothesized that changes in plasma TMAO levels related to LC supplementation affect bone metabolism
Rapid Weight Loss: While semaglutide is effective for weight loss, rapid shedding of pounds can lead to muscle loss, including the muscles that help regulate blood pressure, increasing fainting risk
Titration plan: use gradual dose escalation to reduce gastrointestinal side effects
In practice, most clinicians would likely taper tirzepatide down before initiating retatrutide to manage overlapping GI side effects and assess the new compound's individual response
Metabolites 12 , 1026 (2022)
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