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True vitamin B12 overdose is exceptionally rare because it is water-soluble and excess amounts are excreted through urine

Research published in the Journal of Nutritional Biochemistry (PubMed PMID 22452586) confirmed that CLA supplementation significantly reduced LPL activity in adipose tissue and increased fat oxidation in skeletal muscle in both animal and human study contexts, supporting the mechanistic basis for CLAs anti-fat-storage effect

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